Rhabdomyosarcoma is a rare cancer, but it’s the most common type of soft tissue cancer in kids with approximately 350 new cases per year in the U.S. and 5-7 cases per year in Ireland.
There are 2 subtypes: Alveolar (ARMS) and Embryonal rhabdomyosarcoma  (ERMS). While Ebryonal is more common in children under 10 years; Alveolar subtype affects older children and teenagers and usually has worse prognosis.

Pax3/Foxo1 fusion positive subtype of ARMS

It appears that the expression of PAX3-FOXO1 fusion in Alveolar Rhabdomyosarcoma (ARMS) tumor samples portends a worse outcome.
Unfortunatelly Slav’s  results show PAX3-FOXO1 fusion and we were told by his oncologist that Slav’s chances to survive is 5% in next years since diagnoses (January 2018)

Details of Slav’s diagnoses

Slav’s genomic results identified 5 amplifications of following genes:
MDM2, MDM4, PIM1, FRS2 and IGF1r.
+ PAX3/FOXO1 transcription/fusion.

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